Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:coagulation cascade pathway
go back to main search page
Accession:PW:0000474 term browser browse the term
Definition:The coagulation cascade is the series of events proceeding via the tissue factor (extrinsic) or the contact activation (intrinsic) pathway and converging in the formation of fibrin clots. Several anticoagulation systems are in place to modulate the pathway. The coagulation cascade and the complement pathway of immune responses are connected in a cross talk.
Synonyms:related_synonym: Formation of Fibrin Clot (Clotting Cascade);   blood coagulation, fibrin clot formation;   secondary hemostasis
View Interactive Diagram

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
coagulation cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOH apolipoprotein H ISO RGD PMID:15507263 RGD:1578489 NCBI chr16:55,209,142...55,231,176 JBrowse link
G F10 coagulation factor X ISO RGD PMID:10048754 PMID:12356487 PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 RGD:1580376 RGD:2290183 NCBI chr 3:91,125,097...91,154,000
Ensembl chr 3:91,124,766...91,157,376 		JBrowse link
G F11 coagulation factor XI ISO RGD PMID:10048754 PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 RGD:2290183 NCBI chr 7:132,180,026...132,207,081
Ensembl chr 7:132,180,336...132,208,155 		JBrowse link
G F12 coagulation factor XII ISO RGD PMID:10048754 PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 RGD:2290183 NCBI chr23:79,414,074...79,438,896
Ensembl chr23:79,414,225...79,432,298 		JBrowse link
G F13A1 coagulation factor XIII A chain ISO RGD PMID:16102057 RGD:11352259 NCBI chr17:65,885,498...66,040,026
Ensembl chr17:65,885,658...66,040,040 		JBrowse link
G F13B coagulation factor XIII B chain ISO RGD PMID:16102057 RGD:11352259 NCBI chr25:32,357,540...32,390,349
Ensembl chr25:32,357,993...32,389,973 		JBrowse link
G F3 coagulation factor III, tissue factor ISO RGD PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 NCBI chr20:38,726,690...38,738,457
Ensembl chr20:38,726,798...38,739,408 		JBrowse link
G F5 coagulation factor V ISO RGD PMID:10048754 PMID:12787532 PMID:15147718 PMID:26018600 RGD:11342779 RGD:11352277 RGD:1580372 RGD:2290183 NCBI chr25:59,465,610...59,539,022
Ensembl chr25:59,466,378...59,538,872 		JBrowse link
G F7 coagulation factor VII ISO RGD PMID:10048754 PMID:12356487 PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 RGD:1580376 RGD:2290183 NCBI chr 3:91,109,864...91,122,707
Ensembl chr 3:91,110,380...91,123,327 		JBrowse link
G F8 coagulation factor VIII ISO RGD PMID:2513867 PMID:7721754 PMID:10048754 PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 RGD:1582368 RGD:1582371 RGD:2290183 NCBI chr  X:129,090,140...129,315,343
Ensembl chr  X:129,088,611...129,312,909 		JBrowse link
G F9 coagulation factor IX ISO RGD PMID:10048754 PMID:12356487 PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 RGD:1580376 RGD:2290183 NCBI chr  X:114,618,397...114,650,827
Ensembl chr  X:114,618,639...114,651,365 		JBrowse link
G FGA fibrinogen alpha chain ISO RGD PMID:16102057 RGD:11352259 NCBI chr 7:101,127,554...101,134,881
Ensembl chr 7:101,125,791...101,134,405 		JBrowse link
G FGB fibrinogen beta chain ISO RGD PMID:16102057 RGD:11352259 NCBI chr 7:101,106,468...101,114,566
Ensembl chr 7:101,106,483...101,114,662 		JBrowse link
G FGG fibrinogen gamma chain ISO RGD PMID:16102057 RGD:11352259 NCBI chr 7:101,148,457...101,157,245
Ensembl chr 7:101,148,058...101,157,111 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa ISO RGD PMID:12787532 RGD:11352277 NCBI chr10:2,789,227...2,799,783
Ensembl chr10:2,789,277...2,799,531 		JBrowse link
G PROZ protein Z, vitamin K dependent plasma glycoprotein ISO RGD PMID:23690629 RGD:11352284 NCBI chr 3:91,156,880...91,171,333
Ensembl chr 3:91,157,307...91,171,042 		JBrowse link
G SERPINA10 serpin family A member 10 ISO RGD PMID:23690629 RGD:11352284 NCBI chr24:72,059,523...72,069,989
Ensembl chr24:72,058,780...72,069,085 		JBrowse link
G SERPINC1 serpin family C member 1 ISO RGD PMID:12787532 RGD:11352277 NCBI chr25:55,271,823...55,289,855 JBrowse link
G SERPING1 serpin family G member 1 ISO RGD PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 NCBI chr 1:15,617,122...15,634,540
Ensembl chr 1:15,616,674...15,633,855 		JBrowse link
G TFPI tissue factor pathway inhibitor ISO RGD PMID:12787532 PMID:26018600 RGD:11342779 RGD:11352277 NCBI chr10:73,004,762...73,105,772
Ensembl chr10:73,002,522...73,105,858 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4034
    regulatory pathway 2500
      homeostasis pathway 1295
        cardiovascular system homeostasis pathway 263
          hemostasis pathway 27
            coagulation cascade pathway 20
              altered coagulation cascade pathway 0
paths to the root